Biochem/physiol Actions

Reversible: no

Target IC₅₀: 200 µM against adenylate cyclase

Product does not compete with ATP.

Primary Targetadenylate cyclase

Cell permeable: yes

General description

Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC₅₀ = 200 µM). Reduces PGE₂-induced inhibition of O₂^⋅– production.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.Tamaoki, J., et al. 1993. Prostaglandins45, 363.Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Warning

Toxicity: Irritant (B)